wolff_kishner
(Stranger) 07-10-04 00:38 No 518451 |
Acetals as grignard solvents? | |||||||
Would acetals be acceptable solvents for grignard reactions? In basic conditions, acetals are stable ethers. Since Grignard reactions take place in a basic environment, wouldn't the acetal be indistinguishable from an ether? I have used the search engine and found nothing either supporting or opposing the use of acetals. |
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Rhodium (Chief Bee) 07-10-04 00:50 No 518454 |
Dialkoxymethanes/formaldehyde acetals | |||||||
Dimethoxymethane and diethoxymethane are both very good solvents for Grignard reactions: http://www.arkat-usa.org/ark/journal/200 The Hive - Clandestine Chemists Without Borders |
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wolff_kishner (Stranger) 07-10-04 03:35 No 518471 |
Why aren't they widely used then? | |||||||
Thanks, Rhodium. However, if formaldehyde acetals are good grignard solvents, why aren't they popular? Diethoxymethane would be easy to make and less volatile and dangerous than ethyl ether. |
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Rhodium (Chief Bee) 07-10-04 05:24 No 518482 |
price | |||||||
They are more expensive than ether, and in case an acidic workup is made, formaldehyde may contaminate or react with the product. The Hive - Clandestine Chemists Without Borders |
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