09-17-04 17:33
No 531790
Palladium Catalysts for the Suzuki Cross -Coupling reaction: An Overview of Recent Advances
Fabio Bellina, Adriano Carpita, Renzo Rossi*
SYNTHESIS 2004, No. x, pp 000A–000Vx.x.204
DOI:10.1055/s-2004-831223
Abstract This review with 206 references covers the literature published until March 2004 on the development and applications of new efficient catalyst systems for the Suzuki palladium-catalysed cross-coupling reaction of organoboron compounds with organic electrophiles. Where possible, the relative advantages of the new catalyst systems in this synthetically very important carbon–carbon bond forming reaction have been compared.
......................................
Conclusions
From this review, it is clear that recent advances in the design of palladium catalysts for the Suzuki reaction have resulted in several synthetically useful acquisitions. Thus, as reported in Section 2, palladacycle complexes have been found to be air- and thermally stable catalyst precursors that are suitable for recycling protocols and that can give very high turnover numbers and turnover frequencies. Moreover, some of them have been proven to be able to promote Suzuki reactions of activated and unactivated aryl chlorides, also under aerobic conditions. Thus, these complexes appear to be catalyst precursors superior to traditional palladium/triarylphosphine catalyst precursors, which are only effective for the coupling of certain activated (hetero)aryl chlorides[.
It is better to die on your feet than to live on your knees...Emiliano Zapata
