05-12-04 09:06
No 506613
swim did some research but only to find that codeine will come through an A/B. (not to sure how true this is)
Does anyone know of a way to remove codeine from pseudoephedrine?
(Hive Addict)
05-12-04 14:58
No 506645
Monograph Number: 2488
Title: Codeine
CAS Registry Number: 76-57-3
CAS Name: (5a,6a)-7,8-Didehydro-4,5-epoxy-3-methox
Additional Names: methylmorphine; morphine monomethyl ether; morphine 3-methyl ether
Trademarks: Codicept (Sanol)
Molecular Formula: C18H21NO3
Molecular Weight: 299.36.
Percent Composition: C 72.22%, H 7.07%, N 4.68%, O 16.03%
Literature References: Present in opium from 0.7 to 2.5%, depending on the source, but mostly prepd by methylation of morphine, q.v. Discussion of structure and bibliography: Small, Lutz, "Chemistry of the Opium Alkaloids," U.S. Public Health Reports, Suppl. No. 103, Washington (1932). Prepn of (+)-codeine and racemate: Goto, Yamamoto, Proc. Japan Acad. 30, 769 (1954), C.A. 50, 1052h (1956); of (-)-form: E. J. Bijsterveld, H. J. Sinnige, Rec. Trav. Chim. 95, 24 (1976); H. C. Beyerman et al., ibid. 97, 127 (1978). Manuf from morphine: W. R. Heumann, Bulletin on Narcotics X, 15 (1958). Facile synthesis from thebaine, q.v.: W. G. Dauben et al., J. Org. Chem. 44, 1567 (1979). Toxicity of the hydrochloride: Eddy, Sumwalt, J. Pharmacol. Exp. Ther. 67, 127 (1939). Comprehensive description of codeine and codeine phosphate, q.v.: F. J. Muhtadi, M. M. A. Hassan, Anal. Profiles Drug Subs. 10, 93-138 (1981).
Derivative Type: Monohydrate
Properties: Orthorhombic sphenoidal rods or tablets (octahedra) from water or dil alcohol, mp 154-156° (after drying at 80°). Sublimes (when anhydr) at 140-145° under 1.5 mm pressure. Melts to oily drops when heated in an amount of water insufficient for complete soln, crystallizes on cooling. d420 1.32. [a]D15 -136° (c = 2 in alcohol), [a]D15 -112° (c = 2 in chloroform). pK (15°) 6.05; pH of satd aq soln 9.8. One gram dissolves in 120 ml water, 60 ml water at 80°, 2 ml alcohol, 1.2 ml hot alcohol, 13 ml benzene, 18 ml ether, 0.5 ml chloroform; freely sol in amyl alcohol, methanol, dil acids. Almost insol in petr ether or in solns of alkali hydroxides.
Melting point: mp 154-156° (after drying at 80°)
pKa: pK (15°) 6.05; pH of satd aq soln 9.8
Optical Rotation: [a]D15 -136° (c = 2 in alcohol); [a]D15 -112° (c = 2 in chloroform)
Density: d420 1.32
Derivative Type: Hydrochloride
CAS Registry Number: 1422-07-7
Molecular Formula: C18H21NO3.HCl
Molecular Weight: 335.83.
Percent Composition: C 64.38%, H 6.60%, N 4.17%, O 14.29%, Cl 10.56%
Properties: Dihydrate, small needles, mp ~280° with some decompn. [a]D22 -108°. One gram dissolves in 20 ml water, 1 ml boiling water, 180 ml alcohol. pH about 5. LD50 s.c. in mice: 300 mg/kg (Eddy, Sumwalt).
Melting point: mp ~280° with some decompn
Optical Rotation: [a]D22 -108°
Toxicity data: LD50 s.c. in mice: 300 mg/kg (Eddy, Sumwalt)
Derivative Type: Sulfate
CAS Registry Number: 1420-53-7
Molecular Formula: (C18H21NO3)2.H2SO4
Molecular Weight: 696.82.
Percent Composition: C 62.05%, H 6.36%, N 4.02%, O 22.96%, S 4.60%
Properties: Trihydrate, crystals or cryst powder. One gram dissolves in 30 ml water, 6.5 ml water at 80°, 1300 ml alc. Insol in chloroform or ether. pH: 5.0. Store in airtight containers; protect from light.
CAUTION: May be habit forming: 21 CFR, 329.1 and is a controlled substance (opiate): 21 CFR, 1308.12.
Therap-Cat: Analgesic (narcotic); antitussive.
Therap-Cat-Vet: Analgesic (narcotic); antitussive.
Never had to remove it from pfed compounds.
Other bees might know!
a little less conversation, a little more reaction
(Newbee)
05-12-04 15:10
No 506650
orh i forget to mention its Codeine Phosphate. If the phosphate is anything like the sulfate, one gram dissolves in 1300ml of alky, then pulling the pseudo with cold alky might be enough to do the trick. If anyone has info on the phosphate derivative it would be greatly appericated. im trying to find info myself but not having alot of luck.
(Hive Bee)
05-12-04 16:24
No 506660
It would bee important to remove the Codeine before a/b'ing these pills (if one was going to a/b). Because I think once its turned into free base and mixed with the FB PFED then it would probably be very difficult to seperate.
(Hive Bee)
05-12-04 16:42
No 506661
I just learnt here https://rxsecure.umaryland.edu/courses/P
that 1gm of codeine phosphate is soluble in 325mLs alcohol. This means you would have to dissolve your pfed/codeine in 6.5mLs of alcohol and filter it to get the codeine out (all but 20mgs would be left.) Like as if you could do that
