11-29-01 18:39
No 242349
What's up folks?! Ever since I was 16 years-old, I've been battling major depression, OCD, pessimism, and anxiety. Knowing this, it's safe to assume that I've tried just about every anti-depressant out there, but I've never taken the time to take a look at their chemical structures, until now. Check-out the structure of Effexor(Venlafaxine Hydrochloride): R/S)-1-[2-(Dimethylamino)-1-(4-Methoxyph
Split a piece of wood and I am there. Lift a stone and you will find me.
(Hive Addict)
11-30-01 14:36
No 242697
The paperwork that goes with a box of this stuff says that venlafaxine has virtually no NMDA antagonist effects. Hmmmm, maybe they're full of shit, or maybe in vitro studies are fucking unreliable, because here's the abstract of an interesting patent I found:
Use of substances capable of blocking the production of glutamate for treating tension-type headache
EP1132082
Abstract:
Tension-type headache is treated by interacting with neuronal transmission in relation to pain in connection with headache in a way that prevents or decreases sensitization of second order nociceptive neurons. In particular, treatment is performed by administration of an effective amount of a substance which prevents or decreases central sensitization. Important examples of such substances which interacts with glutamate neurotranmissions, such as glutamate receptor antagonists, such as NMDA receptor antagonists, such as MK-801 or Amitriptylline or Imipramine or Desipramine or Mirtazaprine or Venlafaxine. According to a broader aspect of the invention, tension-type headache is treated by administration of substances which are effective in preventing or decreasing pain in connection with tension-type headache, such as the substances mentioned above.
Split a piece of wood and I am there. Lift a stone and you will find me.
(Hive Bee)
11-30-01 15:03
No 242711
I've been on Effexor before, it is quite a nasty AD if you want to get off of it. Although doctors say that it is not addictive, the body certainly craves for it when you stop taking it,leaving me with whoshing noises in my head and agression attacks for 3 weeks after stopping. The best AD i've been prescribed was Zispin, this had no side effects for me and I stopped using it no problem.
The best treatment for depression is cognitive methods, but if you suffer bi-polar depression you will need medicine.
I have investigated lots of AD's that i've been on, but none of them have been any good for turning into anything more stimulating !
Keep Happy
(Hive Addict)
12-01-01 02:31
No 242959
"but none of them have been any good for turning into anything more stimulating !"
Speaking of "stimulating", I flat-out quit speed, coke and other drugs like them, and as a result, my life is better. MDMA, Ketamine, Weed and tiletamine are all good!
How could I get helpful info on Effexor? Should I email the company that produces it, and ask what it is that makes it a serotonin/noradrenaline re-uptake inhibitor, and not an NMDA antagonist? What should I do? Rhodium? Peace!
Split a piece of wood and I am there. Lift a stone and you will find me.
(Chief Bee)
12-01-01 09:15
No 243025
I guess that doing a search on medline for a SAR on venlafaxine-like compounds would give you some hints. If that doesn't help, then just email them and ask...
(Hive Addict)
12-02-01 21:03
No 243458
I'm searching for info, but I can't find anything useful on effexor-like drugs. Medline? Is it easy to hack artilces from them? What's their url? Peace!
Split a piece of wood and I am there. Lift a stone and you will find me.