dennis_pro
(Stranger) 03-15-02 06:19 No 282827 |
How to methylate alcohols (BOX series)? | Bookmark | ||||||
Hi, folks. I want to make some Shulgin's BOX-series substances. I have 2,5-dimethoxyphenylaminoethanol, prepared from Midodrine. How to methylate OH-group in this substance to produce 2,5,b-trimethoxyphenylethylamine? And as alternative, how to reduct 2,5-dimethoxyphenylaminoethanol to produce 2C-H? J2 with phosphorus will ruin methoxy groups :( Thanks. With best regards, Dennis Prochko |
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Antoncho (Official Hive Translator) 03-15-02 07:07 No 282858 |
Re: How to methylate alcohols (BOX series)? | Bookmark | ||||||
Hey, Volk This has been just recently discussed in the Novel Discourse - i think the thread just went down, it was called "Midodrine: an easy 3-step way to 2C-B" - go ahead, read it. I also asked the question about methylation of alcohols - but, i'm sorry to say that, no one bothered to reply. Maybee someone will answer your post... My congartulations on your joining The Hive - i promise, you're going to like this place! Antoncho P.S. Can i take your PGP-key and put it into the proper section of our forum? If you don't mind... |
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Rhodium (Chief Bee) 03-15-02 15:57 No 282990 |
Re: How to methylate alcohols (BOX series)? | Bookmark | ||||||
Shulgin's way of making the beta-alkoxy compounds is to add a sodium alkoxide to the corresponding nitrostyrene. Any alkylation that would alkylate an amino-alcohol would also alkylate the nitrogen. |
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Antoncho (Official Hive Translator) 03-16-02 09:27 No 283367 |
Re: How to methylate alcohols (BOX series)? | Bookmark | ||||||
Yeah, but in Midodrine the aminogroup is protected w/the amide function! So it shouldn't bee easily methylatable... I can't believe noone on this board knows a single freaking way to methylate an aliphatic hydroxy! Hey, dear chemists, can you lend us a hand? Please? Antoncho |
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