uncle_buck (Stranger)
09-23-02 21:14
No 359793
       Is this ephedrine synth really possible????  Bookmark   

"Ephedrine from Benzaldehyde and D-L Alanine, Heat to yield CO2 + ephedrine."

Does this really work?  Will pure l-isomer alanine work as well?  Is it just the benzaldehyde and alanine in equimolar ratio or some other ratio?  No solvent mentioned, so none needed, I suppose?

Thanks Hive gurus!

ub
  
 
 
 
    Bandil
(Hive Bee)
09-23-02 23:38
No 359843
       I think you are mistaking  Bookmark   

Hi!

I think you are confusing PPA and eph. By using the alanine + BA one will get PPA and not eph. To get eph you would have to use N-methyl-alanine, which is not so easy to come by as alanine.

As for solvent i belive you can find the answer by UTFSE.

Regards
Bandil 		 
 
 
 
    uncle_buck
(Stranger)
09-24-02 15:22
No 360089
       Thanks for the clarification  Bookmark   

PPA, gotcha.  I will FS for the solvent info U'ing TE. 		 
 
 
 
    Aurelius
(Hive Bee)
09-27-02 21:52
No 361506
       solvent  Bookmark   

use toluene or xylene as the solvent (although aurelius believes one may not be absolutely necessary- may even raise yeild)  if picking between the two above, choose xylene, it has a higher boiling point (all three isomers are higher than toluene)  and this allows for a better high boiling solvent for the decarboxylation that occurs at elevated temps.