Vibrating_Lights (Hive Addict)
06-10-03 11:01
No 439013
       BROMO SAFROLE  Bookmark   

Is ity possible to hydrolize Bromosafrole to MdP2POL With
NaOH Heat and H2O?
VL_
Start thinking more like a chemist and less like a criminal 		 
 
 
 
    hypo
(Hive Addict)
06-10-03 12:19
No 439019
       probably.  Bookmark   

to increase reaction speed, you might either work with
an organic solvent/PTC system or in alcoholic solution.
hydrolysis also works in acidic medium (ie. dil. H2SO4).
you'll always get some elimination side-reaction.

now the $100.000-question is: why would you want to do
that? (halo-safrole => MDP2P?) 		 
 
 
 
    Vibrating_Lights
(Hive Addict)
06-10-03 13:27
No 439030
       Bromine Month  Bookmark   

It is national bromine month.
Start thinking more like a chemist and less like a criminal 		 
 
 
 
    hypo
(Hive Addict)
06-10-03 14:18
No 439036
       gee..  Bookmark   

thanks for your cooperation tongue 		 
 
 
 
    Rhodium
(Chief Bee)
06-10-03 14:20
No 439038
       bromosafrole won't give much mdp2pol  Bookmark   

That reaction sounds like you are going to get isosafrole as your major product (elimination instead of substitution).

../rhodium /halide.carbonyl.html is much better, and if you really want MDP2Pol, reduce the product from this reaction.