wolff_kishner (Stranger)
07-23-04 13:35
No 521165
       Chlorine instead of Br in Ketamine and PPA Synths     

Is chlorine an acceptable substitute for bromine in the following syntheses?

1. Bromination of o-chlorophenyl cyclopentyl ketone (Ketamine synthesis)

2. alpha bromination of propiophenone (PPA synthesis from propiophenone)

The nature of the reactions seems to indicate that any halogen will do. Am I wrong? Is bromine specifically required? 		 
 
 
 
    starlight
(Hive Bee)
07-23-04 15:36
No 521190
       I would imagine     

That if you made alpha-chloro propiophenone you would get close to no yield when trying to substitute the halogen with ammonia. 		 
 
 
 
    Organikum
(Wonderful Personality)
07-23-04 21:04
No 521253
       It might work using a pressure bomb, though.     

It might work using a pressure bomb, though.
Schnabufugl!