01-26-04 20:01
No 484774
in post Post 371398 (GC_MS: "simple", General Discourse):
it is mentioned that 2,2,6,6 tetramethylpiperidone was bulky and could have some steric hindrance. does this mean 1. low yield 2. no yield 3. pharmacologically uninteresting fentanyl analog
my main questions are:
if you reacted p-methoxyphenyl-2-bromopropane with tempidone hcl ala seigfried would you get 1-(paramethoxyphenyl-2-propyl) 2,2,6,6 tetrametoxy-4-piperidone in at least 10% yeild? whould reductive amination with aniline and acylation with acetic anhydride yield an opioid type compound? who cares to guess. thanks in advance.
(Chief Bee)
01-27-04 07:48
No 484889
#3 is probably the biggest obstacle. I could only find one fentanyl analog reported in the literature with methyl groups in the 2/6 positions of the piperidine ring, and that was only one methyl group. No fentanyls with 2, 3 or 4 methyl groups in the 2/6 positions could be found. The 2-methylfentanyl was reported in Patent US3923992
The Hive - Clandestine Chemists Without Borders
(Stranger)
01-27-04 10:25
No 484926
thanks. that kind of information is hard to find. Looks like its back to methyl acrylate or the double mannich. My dream compound would be a non-controlled fentanyl analog that is active in the 1-5mg range. I was looking at loperamide molecules on google and I was amazed at the difference between that and fentanyl, and even loperamide is active with the microgranules. I think there is a lot of room for finding an active compound that is not specifically listed. I could mix it with sugar and tell the cops I was making my own rat poison.
(Hive Bee)
01-27-04 10:55
No 484930
if you reacted p-methoxyphenyl-2-bromopropane with tempidone hcl ala seigfried would you get 1-(paramethoxyphenyl-2-propyl) 2,2,6,6 tetrametoxy-4-piperidone in at least 10% yeild?
I'm sure that you would get a considerably higher yield reacting 1-(p-methoxyphenyl)-2-amino-propane (aka PMA) with phorone. The steric hinderance would not be so much of an obstacle as whith the N-alkylation reaction.
“The real drug-problem is that we need more and better drugs.” – J. Ott