04-15-04 01:52
No 500872
in reference to ../rhodium /ketamin
Getting ready to attempt my first ketamine synth. (actually first illicit drug synth) i have a few questions. in step 2 it talks about making o-bromo-benzonitrile instead of o-chlorobenzonitrile. it says to use o-Br-benzamide. can this be made from first step with cuprous bromide instead of cuprous cloride? second question... can i just sub the o-bromo-benzonitrile into step 8 or does other changes need to be made?
thanks
(acetaminophanatic)
04-15-04 04:30
No 500887
I certainly hope this is not your first synthesis....
You could probably sub the o-bromo in step 8.
But then, you could just use benzamide/benzonitrile. And it would be a unique analog. And LEGAL. And maybe even more potent. I would certainly be interested to hear the bioassay...especially the qualitative differences. Did you read the PCP SAR doc on Rhodium's website?
Best, ning.
Catching a buzz @ the Hive
(Stranger)
04-15-04 16:05
No 500959
Well its not my first synth. I have had 2 years of org and an independant lab.... long time ago though. Whats so scary about this synth? I realize grignards are difficult but I have successfully synthed it at least a dozen times. Is this synth doable if I have all the precursors and required equiptment?
(Faglord)
04-15-04 21:45
No 500979
Is this synth doable if I have all the precursors and required equiptment?
What else would you need?
Someone else has already performed it and you seem to have
some lab experience. I guess you won't really know until
you try.
I've got tissues with issues
(acetaminophanatic)
04-16-04 22:35
No 501118
just....ugh....it's so long. Lots of distilling, extracting, stuff like that. Do you have methylamine? Have you ever tried ketamine before? Wouldn't it bee cool to make a K analog? Just in ning's mind, the possibility of both simplifying a procedure, and obtaining a novel never-before-tasted-but-really-likely-to
I guess you won't know if it'll work until you try. I'm definitely interested in bioassay results, though.
If you can run the synth right once, then compare o-chloro K (i.e. ketamine) to the o-bromo, o-iodo, o-methyl, and o-nothing analogs. Then do some amine replacement. N-methyl (K), N-ethyl (like tiletamine), N-isopropyl, N-piperidyl (if you can git it). At that point, you will bee ready to write a small CiHKAL.
It's an addiction, this chemistry thing.
Catching a buzz @ the Hive
(Stranger)
04-26-04 22:26
No 503178
Yes it is long....but i like that. Like the challenge. Anyways, I assumed that the second prep (o-bromo-benzonitrile) was a replacement for the first. In otherwords that I could take the product (o-bromo-benzonitrile) instead of o-chlorobenzonitrile and use it in step 8 to still arrive at K? not an analog like o-bromo k. Was I mistaken? Please if anyone is certain on this let me know, by pm .. reply or flame ... whatever.
Thanks
(Stranger)
04-26-04 23:08
No 503183
also i was planning on sything MA from Chemhacks synth of methylamine (hexamine-HCL)
(Chief Bee)
04-27-04 02:00
No 503214
Anyways, I assumed that the second prep (o-bromo-benzonitrile) was a replacement for the first. In otherwords that I could take the product (o-bromo-benzonitrile) instead of o-chlorobenzonitrile and use it in step 8 to still arrive at K? not an analog like o-bromo k. Was I mistaken?
The o-bromobenzoic acid is made like the o-chlorobenzoic acid, but substituting the CuCl for an equimolar amount of CuBr.
The use of o-bromobenzonitrile in step 8 will not produce actual ketamine, but the very close analog with a bromine atom where ketamine has a chlorine.
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