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2,4,5-chemistry
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Author Topic: 2,4,5-chemistry
Sonson
Junior Member posted 09-15-98 01:47 PM
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Did some lit. search yesterday...
1-(2 bromopropyl)-2,4,5-trimethoxybenzene can (against all odds) be prepared by passing a stream of HBr (from tetralin and Br2??) through a dry CHCl3 solution of asarone. Yield is over 95% or over. (Indian J. Chem. Sect. B 25; pp368-372 -86)
The 2,4,5 trimethoxybensaldehyde could be prepared oxidation with sodiumdichromate in HOAc/benzene of asarone. No yield given.
(Indian J. Chem vol 25B pp981-2 -86)
Enjoy!
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Rhenium
Member posted 09-16-98 06:50 AM
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Sonson,
I has a quick look at those papers today. With regards to the paper where you proceed from asarone, I personally think that the starting material would be of more benefit. 1,2-dimethoxy, 3,4-dimethyleneoxy propenyl benzene would possibly be the mother of all psychoactive materials. Just hit that double bond a bit of Me-NH2 to get your amphetamine and away you go.
Can't recall to much about the other paper, but will get photocopies soon.
Very interesting reading indeed, they refer to the asarone as "an unwanted by-product" !!!! Where's the next plane to India, I want some!!!
Rhenium
Member posted 09-16-98 11:58 AM
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Sonson,
Whoops, there I go shooting my mouth off again *blush*. I mistook the wrong compound in my last post, wish I had had a photocopy then. #6 is asarone, not # 1 which is dillapiole. Still, this is a very interesting paper.
Any idea on sources of the precursors? Says in the paper "waste products"... I can't believe they called dillapiole a waste product... *shakes head*
Thanks for the refs.
Sonson
Junior Member posted 09-16-98 04:28 PM
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Hehe...I see now that it's the "wrong" isomer of asarone that was used! They used the gamma isomer...allyl that is. The easy obtained form of asarone is propenyl, so it wasn't as versatile as I thought it would be!
/Sonson
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