L-DOPA musings -KrZ , Hive Novel Discourse


dormouse (Member) 04-25-00 01:34 No 108863	L-DOPA musings -KrZ	Bookmark
	the Hive BB Novel Discourse L-DOPA musings profile \| register \| preferences \| faq \| search next newest topic \| next oldest topic Author Topic: L-DOPA musings KrZ Hive Bee posted 02-25-2000 10:15 AM -------------------------------------------------------------------------------- L-DOPA --DCM--> L-MDphenylalanine --H2/GAA/EtOH/Pd/C--> MDA ---Paraformaldehyde/H2/GAA/EtOH/Pt/C--> MDMA Would it be impossible to reduce the carboxylic acid without destroying the MD-bridge? Don't know how much this stuff costs. Maybe some pimp enzymatic reaction to form DOPA first from phenylalanine and then on to the shiznits... ;-) Epikur Hive Bee posted 02-25-2000 07:11 PM -------------------------------------------------------------------------------- Some time back I had the same idea and asked the same question! According to the Merck Index there also is a paper on phenylalanine => amphetamine, so I thought the DOPA => MDA might be an easy thing. I was told, though, that it would be a way worse route than about anything else. You might want to search the old messages. Cherrie Baby Hive Bee posted 02-27-2000 11:38 AM -------------------------------------------------------------------------------- I didn't think you could reduce a carboxyllic acid to alkane with Pd/H2. What about: 1) L-MDphenylalanine + MeOH --> L-MDphenylalanine methyl ester 2) + PhCHO --> L-MDphenylalanine methyl ester schiff base 3) + MeX --> alpha-methyl L-MDphenylalanine methyl ester schiff base (X = Br, I) 4) hydrolyse schiff base, hydrolyse ester 5) decarboxylate --> MDA What's the problem with this? Availability of MeX? I think MeBr is used as a fungicide. Epikur Hive Bee posted 02-27-2000 06:45 PM -------------------------------------------------------------------------------- Phenylalanine => d-amphetamine: D.B. Repke at al., J. Pharm. Sci. 67, 1167 (1978) All times are CT (US) next newest topic \| next oldest topic Administrative Options: Close Topic \| Archive/Move \| Delete Topic Hop to: Select a Forum or ArchiveList of Forums:General DiscussionNewbie ForumAcquisition DiscourseChemistry DiscourseMethods DiscourseNovel DiscourseCrystal MethSerious Chemistry ForumThe Hive CouchAdmin Chill-out TentList of Archives:Couch ArchivesClassics!Law and OrderThe litter box.misc. PEAs Contact Us \| the Hive Powered by: Ultimate Bulletin Board, Version 5.43c © Infopop Corporation (formerly Madrona Park, Inc.), 1998 - 2000.