pHarmacist (pHantasticant) 06-05-03 10:21 No 438010				Substituted N-Phenylpropanamides (Rated as: excellent)	Bookmark
						Synthetic analgesics. Synthesis and pharmacology of the diastereoisomers of N-[3-methyl-1-(2-phenylethyl)-4-piperidyl]-N-phenylpropanamide and N-[3-methyl-1-(1-methyl-2-phenylethyl)-4-piperidyl]-N-phenylpropanamide Willem F. M. Van Bever, Carlos J. E. Niemegeers, Paul A. J. Janssen; J. Med. Chem.; 1974; 17(10); 1047-1051. (../rhodium/pdf /fentanyl/3-methylfentanyl.diastereomers.pdf) Abstract: The synthesis of the respective diastereoisomers and enantiomers of N-[3-methyl-1-(2-phenylethyl)-4-piperidylj-N-phenylpropanamide and N-[3-methyl-l-(l-methyl-2-phenylethyl)-4-piperidyl]-N-phenylpropanamide is reported. Analgesic activity is evaluated in the tail withdrawal test in rats. cis-(+)-N-[3-Methyl-l-(2-phenylethyl)-4-piper-idyll-N-phenylpropanamide (23) is found to be an extremely potent analgesic, up to 6684 times morphine. Compound 23 has a fast onset of action, a shorter duration of action than morphine, and an unusually high safety margin. ____ ___ _ Janssen is the ultimate authority when it comes to synthing far-out potent opioids... Accept No Imitations, There Can Only Bee One; www.the-hive.ws
		murmur (HyperLab Bee) 06-09-03 01:57 No 438798				Janssen (Rated as: good read)	Bookmark
						There are some related patents: Patent US3907811 and Patent US3907813