| Beilstein Registry Number | 136380 |
| Beilstein Preferred RN | 94-59-7 |
| CAS Registry Number | 94-59-7 |
| Chemical Name | 5-allyl-benzo[1,3]dioxole |
| 1-allyl-3,4-methylenedioxybenzene | |
| safrole | |
| 4-allyl-1,2-(methylenedioxy)benzene | |
| 5-(2-propenyl)-1,3-benzodioxole | |
| Autoname | 5-allyl-benzo[1,3]dioxole |
| Molecular Formula | C10H10O2 |
| Molecular Weight | 162.19 |
| Lawson Number | 21033 |
| Compound Type | heterocyclic |
| Constitution ID | 120352 |
| Tautomer ID | 109325 |
| Beilstein Reference | 0-19-00-00039, 1-19-00-00617, 2-19-00-00029, 4-19-00-00275, 5-19-01-00553, 6-19 |
| Entry Date | 1988/06/27 |
| Update Date | 2002/04/29 |
| Isolation from Natural Product | radix of Asiasarum heterotropoides var. mandshuricum (China) |
| Ref. 1 | 6188762; Journal; Takasaki, Midori; Konoshima, Takao; Yasuda, Ichiro; Hamano, Tomoko; Tokuda, Harukuni; BPBLEO; Biol.Pharm.Bull.; EN; 20; 7; 1997; 776 - 780. |
| Isolation from Natural Product | Ocotea pretiosa |
| Ref. 1 | 6159391; Journal; Araujo-Junior, Joao X. de; Barreiro, Eliezer J.; Parente, Jose P.; Fraga, Carlos A. M.; SYNCAV; Synth.Commun.; EN; 29; 2; 1999; 263 - 274. |
| Isolation from Natural Product | leaves of Piper aduncum |
| Ref. 1 | 6124808; Journal; Parmar, Virinder S.; Jain, Subhash C.; Gupta, Sangita; Talwar, Sangeeta; Rajwanshi, Vivek K.; et al.; PYTCAS; Phytochemistry; EN; 49; 4; 1998; 1069-1078. |
| Isolation from Natural Product | Piper aduncum |
| Ref. 1 | 6080863; Journal; Parmar, Virinder S.; Jain, Subhash C.; Bisht, Kirpal S.; Jain, Pajni; Taneja, Poonam; et al.; PYTCAS; Phytochemistry; EN; 46; 4; 1997; 597-674. |
| Isolation from Natural Product | Illicium dunnianum by extraction with CH2Cl2 in Soxhlet apparatus for 8 h, removal of solvent and chromatograophy |
| Ref. 1 | 6055384; Journal; Sy, Lai-King; Saunders, Richard M. K.; Brown, Geoffrey D.; PYTCAS; Phytochemistry; EN; 44; 6; 1997; 1099-1108. |
| Isolation from Natural Product | Piper auritum |
| Ref. 1 | 5884642; Journal; Nair, Muraleedharan G.; Sommerville, John; Burke, Basil A.; PYTCAS; Phytochemistry; EN; 28; 2; 1989; 654-655. |
| Isolation from Natural Product | lhe petrol extract of the leaves of Drimys winteri |
| Ref. 1 | 5818808; Journal; Sierra, Jorge R.; Lopez, Jose T.; Cortes, Manuel J.; PYTCAS; Phytochemistry; EN; 25; 1; 1986; 253-254. |
| Isolation from Natural Product | Clausena excavata |
| Ref. 1 | 5718667; Journal; Wu, Tian-Shung; Huang, Shiow-Chyn; Lai, Jeng-Shiow; Teng, Che-Ming; Ko, Feng-Nien; Kuoh, Chang-Sheng; PYTCAS; Phytochemistry; EN; 32; 2; 1993; 449-452. |
| Isolation from Natural Product | leaves of Illicum tashiroi MAXIM., collected on Iriomote Island (Japan) |
| Ref. 1 | 5668828; Journal; Yakushijin, Kenichi; Tohshima, Tomoko; Suzuki, Rika; Murata, Hiroyuki; Lu, Sheng-Ten; Furukawa, Hiroshi; CPBTAL; Chem.Pharm.Bull.; EN; 31; 8; 1983; 2879-2883. |
| Isolation from Natural Product | aus Anethum sowa KURZ |
| Ref. 1 | 3339630; Journal; Baslas; Baslas; RSARAQ; Riechst.Aromen; 22; 1972; 200,202. |
| Isolation from Natural Product | aus Anethum graveolens |
| Ref. 1 | 4298940; Journal; Baslas; Baslas; RSARAQ; Riechst.Aromen; 22; 1972; 155,156,158. |
| Isolation from Natural Product | aus Eugenia bracteata Roxb. |
| Ref. 1 | 3615219; Journal; Narasimha; Nigam; RSARAQ; Riechst.Aromen; 22; 1972; 231,236. |
| Isolation from Natural Product | aus Pogostemon plectranthoides (Desf.) |
| Ref. 1 | 3737643; Journal; Nigam; Ramaiah; RSARAQ; Riechst.Aromen; 22; 1972; 378,388. |
| Isolation from Natural Product | aus aether. Oel v. Saccopetalum tomentosum |
| Ref. 1 | 3339628; Journal; Ramaiah; Nigam; RSARAQ; Riechst.Aromen; 22; 1972; 71,74. |
| Isolation from Natural Product | aus Acorus gramineus |
| Ref. 1 | 3958347; Journal; Fujita et al.; YKKZAJ; Yakugaku Zasshi; 90; 1970; 1367,1371; Chem.Abstr.; 74; 34553; 1971. |
| Isolation from Natural Product | aus d. Blaettern v. Hamamelis virginiana L. |
| Ref. 1 | 3614964; Journal; Messerschmidt; ARZNAD; Arzneim.Forsch.; 18; 1968; 1618. |
| Isolation from Natural Product | aus Magnolia salicifolia |
| Ref. 1 | 3614687; Journal; Fujita; Fujita; CPBTAL; Chem.Pharm.Bull.; 20; 1972; 2251. |
| Isolation from Natural Product | Schinus weinmanniae folius |
| Ref. 1 | 3181171; Journal; Fester et al.; RFIQA6; Rev.Fac.Ing.Quim.Univ.Nac.Litoral; 28; 1959; 9; Chem.Abstr.; 55; 10809; 1961. |
| Isolation from Natural Product | ........... Oil aus Myristica fraga.s |
| Ref. 1 | 3271861; Journal; Bejnarowicz; Kirch; JPMSAE; J.Pharm.Sci.; 52; 1963; 988. |
| Isolation from Natural Product | aether. Oel aus Ocimum basilicum |
| Ref. 1 | 3831982; Journal; Hoerhammer et al.; JPMSAE; J.Pharm.Sci.; 53; 1964; 1033; Chem.Abstr.; 305; 1962. |
| Isolation from Natural Product | Petersiliensamenoel |
| Ref. 1 | 3219839; Journal; Dallacker et al.; MOCMB7; Monatsh.Chem.; 91; 1960; 1089,1096. |
| Isolation from Natural Product | aetherisches Oel von Eremopleila Longifolia F.Muell. |
| Ref. 1 | 3271836; Journal; Della; Jefferies; AJCHAS; Aust.J.Chem.; 14; 1961; 663. |
| Isolation from Natural Product | Bananenaromastoff, Gaschromat. Nachweis |
| Ref. 1 | 301089; Journal; Tressl,R. et al.; ZENBAX; Z.Naturforsch.B Anorg.Chem.Org.Chem.Biochem.Biophys.Biol.; GE; 24; 1969; 781-783. |
| Isolation from Natural Product | im Wurzelholz und in der Wurzelrinde von Sassafras officinalis Nees (Sassafraswurzeloel) |
| Note 1 | Handbook |
| Ref. 1 | 500521; Journal; Power; Kleber; CHZEA6; Chem.Zentralbl.; GE; 68; II; 1897; 42. |
| Ref. 2 | 500511; Journal; Flueckiger; ANPYA2; Ann.Phys.(Leipzig); 158; 1876; 248. |
| Ref. 3 | 500494; Journal; Grimaux; Ruotte; BSCFAS; Bull.Soc.Chim.Fr.; <2> 11; 1869; 465; JLACBF; Justus Liebigs Ann. Chem.; 152; 1869; 91. |
| Ref. 4 | 500524; Journal; Saint-Evre; ANCPAC; Ann.Chim.(Paris); <3> 12; 1844; 107; JLACBF; Justus Liebigs Ann. Chem.; 52; 1844; 397. |
| Ref. 5 | 500525; Book Review / Secondary Ref.; Binder; Buchners Repertorium fuer die Pharmacie 11 <1821>, 346. |
| Isolation from Natural Product | als Hauptbestandteil des aether. Oels der Wurzel und des Wurzelstocks von Asarum arifolium |
| Note 1 | Handbook |
| Ref. 1 | 500496; Journal; Miller; ARPMAS; Arch.Pharm.(Weinheim Ger.); 240; 1902; 377. |
| Isolation from Natural Product | im Oel aus den Blaettern und den gruenen Fruechten von Illicium religiosum (Japanisches Sternanisoel) |
| Note 1 | Handbook |
| Ref. 1 | 500501; Journal; Eijkman; RTCPA3; Recl.Trav.Chim.Pays-Bas; 4; 1885; 39. |
| Ref. 2 | 1518772; Journal; Tardy; BSCFAS; Bull.Soc.Chim.Fr.; <3> 27; 1902; 995. |
| Isolation from Natural Product | im aether. Oel aus der Wurzelrinde von Cinnamomum ceylanicum |
| Note 1 | Handbook |
| Ref. 1 | 500518; Journal; Pilgrim; CHZEA6; Chem.Zentralbl.; GE; 80; I; 1909; 534. |
| Isolation from Natural Product | im Campheroel (Cinnamomum Camphora) |
| Note 1 | Handbook |
| Ref. 1 | 500517; Book Review / Secondary Ref.; Schimmel & Co.; Bericht vom September 1885, 7. |
| Isolation from Natural Product | im aether. Rindenoel von Cinnamomum pedatinervium |
| Note 1 | Handbook |
| Ref. 1 | 500516; Journal; Goulding; JCSOA9; J.Chem.Soc.; 83; 1903; 1099. |
| Isolation from Natural Product | im Massoirindenoel (Cinnamomum, Spezies unsicher) |
| Note 1 | Handbook |
| Ref. 1 | 500368; Journal; Woy; ARPMAS; Arch.Pharm.(Weinheim Ger.); 228; 1890; 40. |
| Isolation from Natural Product | im aether. Muskatnussoel (Ol. Nucis moschatae) |
| Note 1 | Handbook |
| Ref. 1 | 1297408; Journal; Power; Salway; JCSOA9; J.Chem.Soc.; 91; 1907; 2045,2049. |
| Isolation from Natural Product | Vorkommen von Safrol in weiteren aetherischen Oelen |
| Note 1 | Handbook |
| Ref. 1 | 500513; Book Review / Secondary Ref.; Semmler; Die aetherischen Oele, Bd. IV <Leipzig 1907>, S. 144ff. |
| Isolation from Natural Product | im californischen Lorbeerblaetteroel (von Umbellularia californica) |
| Note 1 | Handbook |
| Ref. 1 | 500495; Journal; Power; Lees; JCSOA9; J.Chem.Soc.; 85; 1904; 638. |
| Isolation from Natural Product | Vorkommen im Oel der Fruechte von Illicium verum (Sternanisoel) |
| Note 1 | Handbook |
| Ref. 1 | 504621; Journal; Schimmel & Co.; CHZEA6; Chem.Zentralbl.; GE; 81; I; 1910; 1719. |
| Isolation from Natural Product | Im aether. Oel der Blaetter von Atherosperma moschatum Labill. |
| Note 1 | Handbook |
| Ref. 1 | 504620; Journal; Scott; JCSOA9; J.Chem.Soc.; 101; 1912; 1613. |
| Isolation from Natural Product | Im aether. Oel des Holzes von Cinnamomum glanduliferum Meissn. |
| Note 1 | Handbook |
| Ref. 1 | 504619; Journal; Pickles; JCSOA9; J.Chem.Soc.; 101; 1912; 1437. |
| Isolation from Natural Product | Im aether. Oel der Rinde von Cinnamomum Oliveri Bail. |
| Note 1 | Handbook |
| Ref. 1 | 504618; Journal; Hargreaves; JCSOA9; J.Chem.Soc.; 109; 1916; 751. |
| Isolation from Natural Product | Safrol ist der Hauptbestandteil des Oeles aus dem Holz von Cinnamomum Parthenoxylon Meissn. |
| Note 1 | Handbook |
| Ref. 1 | 504617; Journal; Schimmel & Co.; CHZEA6; Chem.Zentralbl.; GE; 82; I; 1911; 1837. |
| Isolation from Natural Product | im aether. Oel aus den Blaettern von Doryphora Sassafras |
| Note 1 | Handbook |
| Ref. 1 | 506411; Journal; Penfold; PEORAA; Perfum.Essent.Oil Rec.; 13; 273; CHZEA6; Chem.Zentralbl.; GE; 93; IV; 1922; 673. |
| Isolation from Natural Product | im Pichurimbohnen-Oel |
| Note 1 | Handbook |
| Ref. 1 | 506410; Journal; Roure-Bertrand fils; CHZEA6; Chem.Zentralbl.; GE; 93; I; 1922; 360. |
| Isolation from Natural Product | bildet den Hauptbestandteil der aether. Oele aus der Rinde und den Blaettern von Laurelia serrata Bert. |
| Note 1 | Handbook |
| Ref. 1 | 506408; Journal; Fester; Salgado; ANCEAD; Angew.Chem.; 42; 1929; 988. |
| Ref. 2 | 506409; Book Review / Secondary Ref.; Schimmel & Co.; Ber. Schimmel 1927, 61; C. 1927 II, 1518. |
| Isolation from Natural Product | Vorkommen in verschiedenen japanischen aetherischen Oelen |
| Note 1 | Handbook |
| Ref. 1 | 506407; Journal; Anonymus; CHZEA6; Chem.Zentralbl.; GE; 91; III; 1920; 597. |
| Isolation from Natural Product | aus dem aetherischen Oel der Wurzeln von Asarum sieboldii |
| Note 1 | Handbook |
| Ref. 1 | 542486; Journal; Kaku; Kondo; YKKZAJ; Yakugaku Zasshi; 51; 1931; 8, 16; dtsch. Ref. S. 3, 6; Chem.Abstr.; 1931; 1948. |
| Isolation from Natural Product | aus dem aetherischen Oel der Blaetter von Boronia pinnata |
| Note 1 | Handbook |
| Ref. 1 | 542485; Journal; Penfold; JPRSA5; J.Proc.R.Soc.N.S.W.; 62; 1928; 225, 230. |
| Isolation from Natural Product | aus dem aetherischen Oel der Blaetter von Cinnamomum camphora |
| Note 1 | Handbook |
| Ref. 1 | 1365400; Journal; Naito; NKAKB8; Nippon Kagaku Kaishi; 64; 1943; 1125; Chem.Abstr.; 1947; 3776. |
| Ref. 2 | 542484; Journal; Fujita; NKAKB8; Nippon Kagaku Kaishi; 63; 1942; 58, 62; Chem.Abstr.; 1947; 3509. |
| Isolation from Natural Product | aus dem aetherischen Oel der Blaetter von Cinnamomum micranthum |
| Note 1 | Handbook |
| Ref. 1 | 542482; Journal; Fujita; Tamashita; NKAKB8; Nippon Kagaku Kaishi; 65; 1944; 385, 388, 591; Chem.Abstr.; 1947; 3509. |
| Isolation from Natural Product | aus dem aetherischen Oel der Blaetter von Illicium parviflorum |
| Note 1 | Handbook |
| Ref. 1 | 542481; Journal; Foote; JPHAA3; J.Am.Pharm.Assoc.; 27; 1938; 573. |
| Isolation from Natural Product | aus dem aetherischen Oel der Wurzeln von Ligusticum acutilobum |
| Note 1 | Handbook |
| Ref. 1 | 592320; Journal; Noguchi; Kawanami; YKKZAJ; Yakugaku Zasshi; 57; 1937; 783, 788; dtsch. Ref. S. 196, 199; CHZEA6; Chem.Zentralbl.; GE; 108; II; 1937; 4050. |
| Ref. 2 | 512471; Journal; Noguchi et al.; YKKZAJ; Yakugaku Zasshi; 57; 1937; 769, 773; dtsch. Ref. S. 187; Chem.Abstr.; 1938; 3360. |
| Isolation from Natural Product | aus dem aetherischen Oel der Rinde von Nemuaron humboldtii |
| Note 1 | Handbook |
| Ref. 1 | 542478; Journal; Chabeau; Bl. Acad. Med. Belgique; <6> 3; 1938; 46, 52. |
| Isolation from Natural Product | aus dem aetherischen Oel des Holzes von Ocotea pretiosa |
| Note 1 | Handbook |
| Ref. 1 | 542448; Journal; Hickey; JOCEAH; J.Org.Chem.; 13; 1948; 443, 445. |
| Ref. 2 | 542477; Journal; Raoul; Jachan; Rev. Quim. ind.; 19; 1950; 12, 13. |
| Isolation from Natural Product | aus dem aetherischen Oel des Holzes von Sassafras albidum |
| Note 1 | Handbook |
| Ref. 1 | 542448; Journal; Hickey; JOCEAH; J.Org.Chem.; 13; 1948; 443, 445. |