(Member)
04-19-00 06:43
No 122779
(Rated as: good read)
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alpha-cyclohexyl amphetamine analogue
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Author Topic: alpha-cyclohexyl amphetamine analogue
Lilienthal
Member posted 12-18-98 04:25 PM
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Chem. Pharm. Bull. 34, 2071 1986 H. Takahashi e.a.:"Interestingly, S-isomers such as (S)-alpha-cyclohexyl-beta-phenylethylami
Arzneimittelforschung 28, 1561 1978 P. Ghosh e.a.: Synthesis of (R,S)-alpha-cyclohexyl-beta-phenylethyla
Chem. Ber. 67, 1617 1934: Another route.
Lil. Drms. 12, 18 1989 O. Lilienthal: Synthesis from benzaldehyde and nitromethyl-cyclohexane, excellent yields!.
Beagle
Member posted 12-19-98 01:15 AM
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Very interesting. Is there any receptor binding data in that Chem. Pharm. Bull. article? Or is the amphetamine-like activity seen in some pharmacological assay (grooming behavior, increased locomotor activity, etc)? Looking at the structure, seems like it could be acting at PCP or other receptors.
drone 342
Member posted 12-19-98 03:44 PM
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You're getting into some amazing stuff here. THere's a double-phenylated ring compound with a potency 10 times that of d-meth. Interested? I'll post ref's if anyones cares for them.
-drone #342
These are some potent analogs, but I know there are ones out there that leave even these ones in the dust. When I remember to bring them, I'll send y'all thei page nubmers, etc. Still from this you should be able get enough info to keep you plenty busy. -drone #342 Contact Us | the Hive Powered by: Ultimate Bulletin Board, Version 5.39a
Osmium
Member posted 12-21-98 04:12 AM
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Drone: "I'll post ref's if anyones cares for them."
Of course we do. You know that. Want me to say PLEEZE again?
Lilienthal
Member posted 12-21-98 05:30 AM
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Takahashi (Chem. Pharm. Bull. 34, 2071 1986) only gave this short remark and analgesic activities (acid writhing, mice).
Ghosh (Arzneim.-Forschg. / Drug. Res. 28, 1561 1978) found a decrease in motor activity (d-amphetamine gave a strong increase, it's the classical stimulants test). But they used the racemate at 1/10 lethal dose. Maybe it's the opioid (or another, who knows?) activity which dominates at higher doses or with the stereoisomers.
drone 342
Member posted 12-21-98 01:06 PM
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I don't have my ref's with me, but a few of them for 2-benzhydryl-1-methyl-piperidine are:
Helv.Chim.Acta; 37; 1954; 2133,2142,2143;
JACS; 117; 45; 1995; 11124-11133;
CA 57; 2197d; 1962;
JACS; 118; 16; 1996; 3862-3868;
I ca
drone 342
Member posted 12-21-98 01:08 PM
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I think the following ref should also be of interest: JMC; 11; 4; 1968; 792-796
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