dormouse
(Member) 04-19-00 10:23 No 122823 |
formulae for describing kinetics of base catalyzed amide/ether hydrolysii? -rev dron | Bookmark | ||||||
the Hive BB Serious Chemistry Forum formulae for describing kinetics of base catalyzed amide/ether hydrolysii? profile | register | preferences | faq | search next newest topic | next oldest topic Author Topic: formulae for describing kinetics of base catalyzed amide/ether hydrolysii? rev drone Hive Bee posted 01-21-2000 03:54 PM ---------------------------------------- Yes, I'm being a bit lazy, but considering all the stuff I do, I'm entitled every now and then. Just in case anybody has this information at their fingertips, does anybody know the general formula describing the base-catalyzed hydrolisis of amides or esters? For that matter, acid-catalyzed hydrolysis kinetics data is welcome too. ------------------ Ipsa scientia potestas est Bronsted catalysis equation logk = A logKa + C where k is the rate constant for a reaction catalyzed by an acid of ionization constant Ka. So, when k is plotted against Ka for catalysis of a given reaction by a series of acids a staight line should be obtained with slope A and intercept C. Nitriles or amides can also be hydrolyzed in base...due to the high stability of the amide function however, acidic conditions are usually used...the reaction is driven by protonation of the amine generated, forming an ammonium ion. Because acid is consumed, it is an acid-induced rather than catalyzed reaction: Methylamine + acetate ion <--OH-/H2O-- this the kind of info you're looking for, or more kinetics?
|
||||||||