psyloxy
(Hive Bee) 05-13-00 22:59 No 3770 |
An Idea for AMT and AET | Bookmark | ||||||
AMT: Indole-3-COH + EtNO2 --> Indole-3-CH=C(NO2)-CH3 Indole-3-CH=C(NO2)-CH3 + SnCl2*2H2O --> Indole-3-CH2-C(=NOH)-CH3 Indole-3-CH2-C(=NOH)-CH3 + NaHSO4 --> Indole-3-CH2-C(=O)-CH3 Indole-3-CH2-C(=O)-CH3 + Mg + AcONH4 + AcOH + MeOH --> AMT [or use any other ketone --> amine method you like] AET: just use nitropropane. Looks quite nice to me. If it works, great. The chems are no problem to get. Nitropropane is legal like NaCl. NaHSO4, SnCl2*H2O and Mg/AcOH/AcONH4/MeOh are also no problem. But what about indole-3-COH ? It could be that it is expensive as hell. Couldn't one make it from indole [which is cheap I think] ? What about this: Indole + HCOH + (Me)2NH --> Indole-CH2-N(Me)2 [that works for sure] Indole-CH2-N(Me)2 + oxidizing agent --> Indole-COH + HN(Me)2 --psyloxy-- |
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phaidon (Newbee) 05-13-00 23:21 No 3775 |
Re: An Idea for AMT and AET | Bookmark | ||||||
psyloxy! You can buy indole-3-CHO a.k.a. indole-3-carboxaldehyde from either a chem supplier or our beloved overly expensive JLF. (Think it 's quite expensive, that is), they got 5-MeO-I-3-CHO as well but that's at $95 / gr. I think. Check their site. Laters, -- phaidon, son of apollon I scorched the Earth, now what do I do tomorrow? |
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Rhodium (Chief Bee) 05-14-00 16:06 No 4048 |
Re: An Idea for AMT and AET | Bookmark | ||||||
There is a procedure for making indole-3-CHO from indole in http://rhodium.lycaeum.org/chemistry/vil http://rhodium.lycaeum.org |
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psyloxy (Hive Bee) 05-14-00 16:20 No 4051 |
Re: An Idea for AMT and AET | Bookmark | ||||||
Ok, ok, forget about indole-3-carboxaldehyd for a moment. I just want to hear that magical 'yes' or 'no'. I mean, it looks quite plausible but so have other things to me that were worth shit in the end. --psyloxy-- |
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Rhodium (Chief Bee) 05-14-00 17:09 No 4065 |
Re: An Idea for AMT and AET | Bookmark | ||||||
I see no reason for your synth to not work in theory, but there could be a few modifications: Nitroalkene => indolylacetone could be done with Fe/acetic acid as in Pihkal #109. Indolylacetone => AMT could be done with NaBH3CN or NaBH to increase yields. http://rhodium.lycaeum.org |
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