cHiLLy
(Stranger) 11-09-02 23:41 No 378176 |
Patent: Prep. of Lysergic Acid Amides | Bookmark | ||||||
EDIT Preperation of amides of lysergic acid, by forming a mixed anhydride of lysergic and sulfuric acids, and then reacting the mixed anhydride with a nitrogenous base. Room temperature reactions. Patent US2774763 Apologies for not originally elaborating further immediately. |
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Rhodium (Chief Bee) 11-10-02 01:45 No 378212 |
Not a repost, but you could have extrapolated more | Bookmark | ||||||
It is briefly mentioned in Post 277187 (Stonium: "Re: LSA Merck Entry", Newbee Forum) - but not especially prominently. It would however be very nice if you would give a brief summary of the patent, and describe what interesting features in it made you want to post it here (there are hundreds of LSD-related patents out there, what made this special enough to warrant its own thread here?). |
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cHiLLy (Stranger) 11-10-02 06:54 No 378289 |
explanation | Bookmark | ||||||
From the patent: My novel process conveniently can be considered as a two step process comprising first the formation of a mixed anhydride of lysergic and sulfuric acids, and second the formation of the desired lysergic acid amide by reacting the mixed anhydride with a nitrogenous base. The amide of lysergic acid is prepared from the mixed anhydride by reacting the latter compound with a nitrogenous base containing at least one active hydrogen attatched to the nitrogen. The reaction is rapid, completed within a few minutes. Whe less basic amines are employed, it is desirable to allow a reaction period of up to 20 minutes. For the prep. of the mixed anhydride, lysergic acid or a basic, ie, metallic or metalloid salt thereof, can be employed. For this synth the term 'lysergic acid' includes the isomers of lysergic acid, d-lysergic acid, l-lysergic acid, d-isolysergic acid, and l-isolysergic acid. Also included are acids closely related to lysergic acid, ex.: 5,6-dihydrolysergic acid and is acyl derivitives and 10,11-dihydroisolysergic acid. They lysergic acid compound can be anhydrous or hydrated. Also, ideas for aquisition of the neccessary sulfur trioxide, examples and elaborations of the methods expounded above. |
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terbium (Old P2P Cook) 11-10-02 19:14 No 378381 |
Historical interest? | Bookmark | ||||||
This is an ancient process. It would seem to be of only historical interest. I doubt that SO3 has any advantage over the many other coupling agents. Baseline Does Not Exist. |
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cHiLLy (Stranger) 11-10-02 19:27 No 378382 |
quote | Bookmark | ||||||
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