Methylone aka Explosion

Bumblebee · Thu May 26, 2005 5:36 am

does anyone know more about an interesting stuff i think.
i came across it as i got a email:

New drug 'Explosion' banned
---------------------------

AMSTERDAM - Explosion, the chemical drug that could be purchased in many
Dutch smart shops in the last few months, has now been banned.
According to the inspection, Explosion is a non-registered medicine and
these cannot be sold. The new drug is offered as an air freshener in small
tubes which contain vanilla oil and methylon.

Methylon is somewhat similar to MDMA, both in chemical structure and in its
effects. MDMA is the active substance in XTC pills. Up until now there is
little knowledge about the actual effects of the drug. Experts are still
doing research. The risks of the drug seem to be the same as those of XTC.

I did some reaearch, and fond the following:

Explosion started to work within about 15-20 minutes. It came on pretty much like MDMA. There was whole-body shivering, concentrated breathing, and moderate to extreme euphoria. The euphoria lasted about 2 full hours with the peak lasting until 45-minutes to an hour.... Overall the trip was strikingly close to MDMA, with the highs not as high, the lows not as low and a shorter overall trip....
-- (by geeb, posted 23 January 2005, Drugs-Forum)

Erowid:
Effect:
With intake on an empty stomach, the onset comes very quick. It takes a maximum of 1 hour and 15 minutes, before the first effects begin. Duration of effects: 3 - 6 hours. The consciousness altering effect gives a happy, relaxed, high, floating feeling and a strong desire to make contact, to talk and to intimacy. One becomes more loose. The perception intensifies and music sounds different. The body tingles and a blissful state comes over the user. The effect is constant and does not come in waves as with XTC. The stimulating effect makes energetic, clear minded and alert. Users have a greater stamina and can therefore dance for many hours. During the effect one should take in enough water or other non-alcoholics to avoid dehydration. Jaw tension may occur.

2-methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one
it seems to be "MDMC" 3,4-Methylendioxymethcathinone...

any suggestions? Synth? are you interested in general? Did any Swim/swiy try it?

joe_aldehyde · huxleys associate

synthesis could be from piperonal + EtNO2 (see hive files for catalysts in nitroalcohols), subsequent oxidation to the benzylic ketone, protection with 1,2-ethanedithiol, reduction of the nitro group to the ketone, reductive amination, deprotection of the 1,3-dithiane to the ketone. just as interesting would be the ephedrine counterpart, that is (3,4-methylenedioxyphenyl)-2-methylaminopropane-1-ol (i already earned my degree in nomenclature, hah!)

capricorn · Thu May 26, 2005 5:08 pm

Or if the Akabori reaction works sattisfactory, Piperonal + N-Methyl-Alanine followed by oxidation of the formed hydroxy group should lead directly to Methylone. Or using the more easily obtaind Alanine to get the MDA counterpart which mabye still is legal?

joe_aldehyde · huxleys associate

over at the other post about the akabori reaction, there was the ref. given for piperonal with n-methylalanine. anybody gonna try that Wink

IndoleAmine · Dreamreader Deluxe

Isonitrosopropiophenones can be made easily (have ref upon request) and are a viable intermediate for such enterprises, methinks..

NOTE: Removed the arguments... I_A, joe_aldehyde... dont even start.. im getting sick of it.

-AC

Star-light · Blacklight bulb

Methylenedioxypropiophenone can be produced by Friedel-crafts alkylation of Benzodioxole with propionyl chloride, using AlCl3 as a catalyst and Nitromethane as a solvent. The nitromethane stops the AlCl3 from damaging the MD bridge. The workup of the reaction is a bitch though (the way I did it) and is in need of improvement.

I don't have a writeup available at the moment, as it is in my PMs at the Hive, but the reaction has been proven to work. Kinetic will be able to throw more light upon it when he is back (maybe another couple of weeks I guess).

ApprenticeCook · DILLIGAF

I have made the mods to this topic to remove the pointless arguments...

As for names... IUPAC the official name system defines you drop the 'e' when adding mid-name numbering systems...
so it would be propan-1-ol
NOT propane-1-ol or propan-1-ole or propane-1-ole

http://www.iupac.org <-- Check it out... and
http://www.google.com for 'basic' descriptions if you need them..

END OF DISCUSSION

-AC

joe_aldehyde · huxleys associate

What can we expect from the akabori reaction? i'm calling for reference or previous experience with this reaction. post away, bees!