|
Author |
Message |
nubee
Master Archiver
|
Joined: 18 Feb 2005 |
Posts: 215 |
Location: homeless |
18648.26 Points
|
|
l-dopa
Wed Apr 20, 2005 8:02 am |
|
|
can anything be done from this...??
|
|
Back to top |
|
|
CherrieBaby
chouchou
|
Joined: 01 Mar 2005 |
Posts: 67 |
|
3070.02 Points
|
|
Wed Apr 20, 2005 11:09 pm |
|
|
Take alpha-methyl-DOPA (aka methyldopa, Aldomet) instead.
(1) Decarboxylate the amino acid of alpha-methyl-DOPA to get 3,4-dihydroxy-phenylisopropylamine (aka dihydroxy-amphetamine)
(2) Turn the catechol into a methylenedioxy and you have MDA
I'm told you can't do rxn 2 because the amino will interfere with the methylenation. That you'd need to protect the amino before (2) and deprotect afterwards. I still can't understand why! Surely the phenol groups are acidic and undergo methylenation via a Williamson synth. The amino is basic, add alkali to it (as in the Williamson) and you don't get -NH(-). Add alkali to phenol and it gives -O(-)
Can someone tell me why alpha-methyl-DOPA to MDA won't go? |
|
Back to top |
|
|
|
|