semi synthetic flavanoids, 30X stronger then diazepam

stratosphere · Sat May 21, 2005 7:42 pm

Flavonoids and the Central Nervous System: from Forgotten Factors to Potent Anxiolytic Compounds
Paladini A.C.1; Marder M.1; Viola H.1; Wolfman C.1; Wasowski C.1; Medina J.H.1
Journal of Pharmacy and Pharmacology, 1 May 1999, vol. 51, no. 5, pp. 519-526

Abstract:
The list of activities of plant flavonoids did not include effects on the central nervous system (CNS) up to 1990, when our laboratory described the existence of natural anxiolytic flavonoids. The first of these was chrysin (5,7-dihydroxyflavone), followed by apigenin (5,7,4-trihydroxyflavone) and flavone itself. Semisynthetic derivatives of flavone obtained by introducing halogens, nitro groups or both in its molecule, give rise to high affinity ligands for the benzodiazepine receptor, active in-vivo; 6,3-dinitroflavone, for example, is an anxiolytic drug 30 times more potent than diazepam.
The data collected in this paper make clear that some natural flavonoids are CNS-active molecules and that the chemical modification of the flavone nucleus dramatically increases their anxiolytic potency.

Comments
i came across this abstract Flavonoids and the Central Nervous System: from Forgotten Factors to Potent Anxiolytic Compounds which claims that 6,3' dinitroflavone is 30X more potent then diazepam.
i was curious to see the synthitic procedure used.

Note : re-formatted by java

opa · Thu Aug 11, 2005 1:38 am

and what was the synthetic procedure ?

java · Consumer

stratosphere....was referring to the" synthesis of 6,3' dinitroflavone is 30X more potent then diazepam" which is to be found in the journal he's requesting .........java

fcknut · Thu Aug 25, 2005 2:23 pm

got this if it's still wanted - rapidshare's being annoying at the mo tho - will try again later...

let me know if you still want it though.

fcknut · Thu Aug 25, 2005 2:34 pm

OK - used a different one...

http://www.megaupload.com/?d=361M03QA

opa · Thu Sep 08, 2005 1:22 am

wow, thousand thanks to you, fcknut, surely i'm interested in gaba-smashing compounds and their synths Smile