06-10-02 01:33
No 319230
Does anyone know anything about the precursors mentioned on ../rhodium /levorph
Especially:
2-(1,4-Cyclohexadienyl)ethylamine
and
p-Methoxyphenylacetyl chloride
I cannot find any information on these, do they have any other names? Any info on synthesis of these would be greatly appreciated!
(Chief Bee)
06-10-02 02:37
No 319238
The first one is made though birch reduction of 2-phenetylamine, and the second through chlorination of 4-methoxyphenylacetic acid with SOCl2. One synthesis of the latter precursor can be found at ../rhodium /willger
If you have the necessary equipment to perform the above reactions I'll help you further.
(Newbee)
06-10-02 10:24
No 319328
Preparation of useful intermediates of dextrorphan
Passarotti, C. M.; Valenti, M.; Grianti, M.
Boll.Chim.Farm. 1993, 132: 11 472-474
Dextrorphan is the main metabolite of Dextromethorphan, a drug with high anti-tussive activity.In this preliminary work we report on the synthesis of two essential intermediates for its preparation: 2-(1-cyclohexenyl)ethyl amine and (R;S)-1-(4-methoxy-benzyl)-2-methyl-1,2,
you can use 2-(1-cyclohexenyl)ethyl amine in place of the dihydro phenethylamine. i think this can be prepared from cyclohexanone starting with a grignard. the above ref is from the belstein databases - perhaps some kind bee with access to the complete article could post it or alternatively pm blondie.