Megatherium (Hive Bee) 10-24-03 00:44 No 466412				Nordiazepam & Nitrazepam (Rated as: excellent)
						Nordiazepam Patent DE1136709 JOC (1961) vol 26 p 4936 JOC (1962) vol 27 p 562 Nitrazepam Patent US3109843 Patent US3116203 Patent US3123529 Patent DE1136709 Patent DE1145626 JMC (1963) vol 6 p 261
		Rhodium (Chief Bee) 10-24-03 18:26 No 466525				Nordiazepam & Nitrazepam (Rated as: excellent)
						That's a good complement to these writeups by the late PsychoChemist: Nordiazepam (../rhodium /nordiazepam.html) Nitrazepam (../rhodium /nitrazepam.html) Here are the above listed articles: Nitrazepam Quinazolines and 1,4-Benzodiazepines. X. Nitro-Substituted 5-Phenyl-1,4-benzodiazepine Derivatives L. H. Sternbach, R. Ian Fryer, O. Keller, W. Metlesics, G. Sach, N. Steiger J. Med. Chem. 6, 261-265 (1963) (../rhodium/pdf /benzodiazepines-10.nitrazepam.pdf) Abstract The general synthesis of nitro-substituted 1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-ones from aminonitrobenzophenones and the specific synthesis of 1,3-dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-ones by direct nitration of the corresponding unsubstituted benzodiaxepinones is described. The position of the nitro group was proved by its replacement by chlorine via a Sandmeyer reaction of the amine obtained by reduction. Alkylation of some of the benzodiazepinones gave the corresponding 1-alkyl derivatives. Mild acid hydrolysis of nitrobenzodiazepinones and 1-alkyl-nitrobenzodiazepinones led to several previously undescribed aminonitrobenzophenones. 2-Amino-5-nitrobenzophenone was converted aia the a-oxime into the corresponding 2-chloromethyl-6-nitro-4-phenylquinazoline 3-oxide and this compound when treated with nucleophilic reagents gave, by a ring expansion, 1,3-dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one 4-oxide. The pharmacological properties of three nitrobenzodiazepine derivatives are reported. These compounds showed a low toxicity combined with sedative, muscle relaxant and anticonvulsant properties. Nordiazepam Quinazolines and 1,4-Benzodiazepines. IV. Transformations of 7-Chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine 4-Oxide L. H. Sternbach, E. Reeder J. Org. Chem. 26, 4936-4941 (1961) (../rhodium/pdf /benzodiazepines-04.nordiazepam.pdf) Abstract 7-Chloro-2-methylamino-5-phenvl-3H-1,4-benzodiazepine 4-oxide (I) and its acetyl derivative (II) can be hydrolyzed to 7-chloro-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one 4-oxide (III). Other methods are described for the synthesis of this compound and its conversion into pharmacologically active beneodiazepinones. 1,3-Dihydro-2H-1,4-benzodiazepine-2-ones and Their 4-Oxides S. C. Bell, T. S. Sulkowski, C. Gochman, S. J. Childress J. Org. Chem. 27, 562-566 (1962) (../rhodium/pdf /benzodiazepine-2-ones.nordiazepam.pdf) Abstract Alcoholic sodium hydroxide converts 6-chloro-2-chloromethyl-4-phenylquinazoline 3-oxide (I) into 7-chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepine-2-one 4-oxide (II). 7-Chloro-5-phenyl-1,3-dihydro-2H-1,4benzodiazepine-2-one (III) was prepared by reduction of II and by several alternate routes. A number of analogs were made.
		Megatherium (Hive Bee) 10-25-03 14:45 No 466678				Thanks, now we 've got the articles online :-)
						Thanks, now we 've got the articles online . In the future, there is more to come about the zepams.
		eXcidium (Stranger) 02-02-04 18:22 No 486061				Such as a full synthesis Of Flunitrazepam? ;)
						Such as a full synthesis Of Flunitrazepam? ;) Let God Die And Rot
		Megatherium (Hive Bee) 02-26-04 20:29 No 491267				Post deleted on request
						(empty)
		Tricky (Stunning) 02-26-04 20:53 No 491270				offtopic :)
						Rated by me as terrible offtopic! Sorry, it's not about chemistry... Only my own opinion. Flunitrazepame is more dangerous then all opioids all together... Sorry for all I said above, cause I tried this shit on my own skin... -who dares, wins-
		Megatherium (Hive Bee) 02-27-04 04:36 No 491336				Off-topic?
						Why is a reference to the patents of flunitrazepam off-topic? Pharmacologically speaking, flunitrazepam is a hypnotic - just like nitrazepam, and unlike nordazepam which is a anxiolytic.   Flunitrazepam is more potent (dose being 1 - 2 mg) than nitrazepam (dose = 5 mg) though. Second, I only answered the question: Such as a full synthesis Of Flunitrazepam? ;) If my chemical appropriate answer is ought to be off-topic, why wasn't the above question rated that way to begin with?  It could just as well have saved me the effort to find the information. Well, I just deleted the post & hope everybody can sleep well now  .
		starlight (Hive Bee) 02-27-04 12:05 No 491390				own post
						i think he was referring to his own post as off topic.
		Rhodium (Chief Bee) 09-20-04 14:49 No 532376				Review Article: 1,4-Benzodiazepines (Rated as: excellent)
						Review Article: 1,4-Benzodiazepines Scott J. Childress & M.I. Gluckman J. Pharm. Sci. 53(6), 577-590 (1964) (../rhodium/pdf /1.4-benzodiazepines.review.pdf) The Hive - Clandestine Chemists Without Borders